Biological interactions of CYP2C19 genotypes with CYP3A4*18 CYP3A5*3 and MDR1-3435 in living donor liver transplantation recipients

摘要

BackgroundPolymorphisms in CYP2C19 are related to the metabolic oxidation of drugs to varying degrees. The CYP3A4*18, CYP3A5*3, and MDR1-3435 variant alleles are very important, particularly in tacrolimus metabolism in organ transplant rejection.