首页> 美国卫生研究院文献>Systems and Synthetic Biology >On an infrastructure to support sharing and aggregating pre- and post-publication systems biology research data
【2h】

On an infrastructure to support sharing and aggregating pre- and post-publication systems biology research data

机译:在支持共享和聚集出版前和出版后系统生物学研究数据的基础架构上

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

The move towards in silico experimentation has resulted in the use of computational models, in addition to traditional experimental models, to generate the raw data that is analysed and published as research findings. This change requires new methods to be introduced to facilitate independent validation of the underlying models and the reported results. The promotion of co-operative research has the potential to help to both validate results and explore wider problem areas. In this paper we leverage and extend two existing software frameworks to develop an infrastructure that has the potential to both promote the sharing of data between researchers pre-publication and enable access to the data for interested parties post-publication. The pre-publication sharing of data would enable larger problem spaces to be explored by distributed research groups; enabling access to the data post-publication would allow reviewers and the wider community to independently verify the published results which would, in the longer term, help to increase confidence in published results. The framework is used to perform reproducible and numerically validated individual-based computational experiments into the onset of colorectal cancer. Existing results are verified and new insights into the top-down versus bottom-up hypothesis of colorectal crypt invasion are given.
机译:走向计算机模拟实验的结果是,除了传统的实验模型之外,还使用了计算模型来生成原始数据,这些原始数据将作为研究结果进行分析和发布。此更改需要引入新方法,以促进对基础模型和报告结果的独立验证。促进合作研究可能有助于验证结果并探索更广泛的问题领域。在本文中,我们利用并扩展了两个现有的软件框架来开发基础结构,该基础结构既有可能促进发布前研究人员之间的数据共享,又可以使感兴趣的各方在发布后访问数据。发布前的数据共享将使分散的研究小组能够探索更大的问题空间;允许在发布后访问数据将允许审阅者和更广泛的社区独立地验证已发布的结果,从长远来看,这将有助于增加对已发布结果的信心。该框架用于对结肠直肠癌的发作进行可复制且经过数字验证的基于个体的计算实验。验证了现有结果,并给出了对自上而下与自下而上的大肠隐窝浸润假说的新见解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号