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Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

机译:使用三分配器笛卡尔打印机的生物打印的细胞构造物的生存力。

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摘要

Tissue engineering has centralized its focus on the construction of replacements for non-functional or damaged tissue. The utilization of three-dimensional bioprinting in tissue engineering has generated new methods for the printing of cells and matrix to fabricate biomimetic tissue constructs. The solid freeform fabrication (SFF) method developed for three-dimensional bioprinting uses an additive manufacturing approach by depositing droplets of cells and hydrogels in a layer-by-layer fashion. Bioprinting fabrication is dependent on the specific placement of biological materials into three-dimensional architectures, and the printed constructs should closely mimic the complex organization of cells and extracellular matrices in native tissue. This paper highlights the use of the Palmetto Printer, a Cartesian bioprinter, as well as the process of producing spatially organized, viable constructs while simultaneously allowing control of environmental factors. This methodology utilizes computer-aided design and computer-aided manufacturing to produce these specific and complex geometries. Finally, this approach allows for the reproducible production of fabricated constructs optimized by controllable printing parameters.
机译:组织工程已将其重点集中在构建无功能或受损组织的替代品上。三维生物打印在组织工程中的应用产生了用于细胞和基质打印以制造仿生组织构造的新方法。为三维生物打印而开发的固态自由形式制造(SFF)方法使用增材制造方法,即以逐层方式沉积细胞和水凝胶的液滴。生物印刷的制作取决于将生物材料具体放置到三维结构中的情况,并且印刷的构建物应紧密模拟天然组织中细胞和细胞外基质的复杂组织。本文重点介绍了笛卡尔生物打印机Palmetto Printer的使用,以及在控制环境因素的同时生产空间有序,可行的结构的过程。这种方法论利用计算机辅助设计和计算机辅助制造来产生这些特定和复杂的几何形状。最后,这种方法允许可重现的通过可控制的印刷参数优化的结构的生产。

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