The effects of glomerular and tubular renal progenitors and derived extracellular vesicles on recovery from acute kidney injury

摘要

BackgroundMesenchymal stromal cells (MSCs) and renal stem/progenitors improve the recovery of acute kidney injury (AKI) mainly through the release of paracrine mediators including the extracellular vesicles (EVs). Several studies have reported the existence of a resident population of MSCs within the glomeruli (Gl-MSCs). However, their contribution towards kidney repair still remains to be elucidated. The aim of the present study was to evaluate whether Gl-MSCs and Gl-MSC-EVs promote the recovery of AKI induced by ischemia-reperfusion injury (IRI) in SCID mice. Moreover, the effects of Gl-MSCs and Gl-MSC-EVs were compared with those of CD133⁺ progenitor cells isolated from human tubules of the renal cortical tissue (T-CD133⁺ cells) and their EVs (T-CD133⁺-EVs).