PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies

机译：PEG-熊果酸缀合物：合成和体外释放研究

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摘要

A highly water-soluble macromolecular compound of ursolic acid with monomethoxypoly(ethylene glycol) (mPEG) was prepared. The physicochemical properties and stabilities under different conditions were investigated. By PEG conjugation, greatly increased water solubility was obtained, and the results showed that this conjugate was a potential prodrug for the oral delivery of ursolic acid.

机译：制备了熊果酸与单甲氧基聚（乙二醇）（mPEG）的高水溶性高分子化合物。研究了不同条件下的理化性质和稳定性。通过PEG缀合，获得了大大增加的水溶性，并且结果表明该缀合物是用于口服递送熊果酸的潜在前药。

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期刊名称 Scientia Pharmaceutica
作者
Marina Zacchigna; Francesca Cateni; Sara Drioli; Giuseppe Procida; Tiziano Altieri;
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作者单位

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年(卷),期 2014(82),2
年度 2014
页码 411–421
总页数 11
原文格式 PDF
正文语种
中图分类药学;
关键词
Ursolic acid Monomethoxypoly(ethylene glycol) Conjugation Solubility;

机译：熊果酸;单甲氧基聚乙二醇;共轭;溶解度;

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专利

1. PEG-Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies [J] . Marina Zacchigna, Francesca Cateni, Sara Drioli, Scientia pharmaceutica . 2014,第2期

机译：PEG-熊果酸缀合物：合成和体外释放研究
2. PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies [J] . Marina ZACCHIGNA, Francesca CATENI, Sara DRIOLI, Scientia pharmaceutica . 2014,第2期

机译：PEG-熊果酸缀合物：合成和体外释放研究
3. Synthesis and Characterization for PEG-Succinyl-Amino Acidyl-Pterostilbene Conjugates and in vitro Release of Peterogtilbene [J] . Zhang Yue, Zhao Shuchun, Shi Xianxian, Journal of Polymer Materials . 2016,第2期

机译：PEG-琥珀酰基-氨基酸基-蝶亭共轭物的合成，表征及体外分布
4. In Vitro Drug Release To Lower GI Tract Under Physiological pH And Enhanced Bioavailability Of PEG- NSAIDs Conjugates [C] . M.J.N. Chandrasekar, Bigala Rajkamal, M.J.Nanjan, Annual meeting exposition of the Controlled Release Society . 2005

机译：在生理pH和PEG-NSAIDs增强的生物利用度条件下，体外药物释放降低胃肠道
5. Valproic acid-dextran conjugate: Synthesis, characterization and in vitro hydrolysis studies. [D] . Hassan, A. M. Mahbub. 2012

机译：丙戊酸-葡聚糖结合物：合成，表征和体外水解研究。
6. Prazosin-Conjugated Matrices Based on Biodegradable Polymers and α-Amino Acids—Synthesis Characterization and in Vitro Release Study [O] . Ewa Oledzka, Anna Sawicka, Marcin Sobczak, 2015

机译：基于可生物降解的聚合物和α-氨基酸的吡唑嗪共轭基质的合成表征和体外释放研究
7. PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies [O] . Marina ZACCHIGNA, Francesca CATENI, Sara DRIOLI, 2014

机译：PEG-熊果酸缀合物：合成和体外释放研究

PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies

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