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Nanomaterials In Medicine Special Feature Sackler Colloquium: A DNA-based nanomechanical device with three robust states

机译:纳米材料在医学上的特色萨克勒学术讨论会:一种基于DNA的具有三种鲁棒状态的纳米机械装置

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摘要

DNA has been used to build a variety of devices, ranging from those that are controlled by DNA structural transitions to those that are controlled by the addition of specific DNA strands. These sequence-dependent devices fulfill the promise of DNA in nanotechnology because a variety of devices in the same physical environment can be controlled individually. Many such devices have been reported, but most of them contain one or two structurally robust end states, in addition to a floppy intermediate or even a floppy end state. We describe a system in which three different structurally robust end states can be obtained, all resulting from the addition of different set strands to a single floppy intermediate. This system is an extension of the PX-JX2 DNA device. The three states are related to each other by three different motions, a twofold rotation, a translation of ≈2.1–2.5 nm, and a twofold screw rotation, which combines these two motions. We demonstrate the transitions by gel electrophoresis, by fluorescence resonance energy transfer, and by atomic force microscopy. The control of this system by DNA strands opens the door to trinary logic and to systems containing N devices that are able to attain 3N structural states.
机译:DNA已被用于构建各种设备,从受DNA结构转变控制的设备到受添加特定DNA链控制的设备。这些序列依赖的设备实现了纳米技术中DNA的希望,因为可以在同一物理环境中单独控制各种设备。已经报道了许多这样的设备,但是除了软盘中间状态或什至软盘端状态之外,它们中的大多数还包含一个或两个结构上健壮的端状态。我们描述了一个系统,在该系统中可以获得三个不同的结构健壮的最终状态,所有这些状态都是由于将不同的固定链添加到单个软盘中间件而导致的。该系统是PX-JX2 DNA设备的扩展。这三种状态通过三种不同的运动相互关联,即两次旋转,≈2.1-2.5nm的平移和两次螺旋旋转(将这两种运动结合在一起)。我们通过凝胶电泳,荧光共振能量转移和原子力显微镜证明了过渡。 DNA链对该系统的控制为三元逻辑和包含N个能够达到3 N 结构状态的设备的系统打开了大门。

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