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Risk of bleeding in surgical patients treated with topical bovine thrombin sealants: a review of the literature

机译:外用牛凝血酶封闭剂治疗的外科手术患者的出血风险:文献复习

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摘要

BackgroundOne of the most anticipated, but potentially serious complications during or after surgery are bleeding events. Among the many potential factors associated with bleeding complications in surgery, the use of bovine thrombin has been anecdotally identified as a possible cause of increased bleeding risk. Most of these reports of bleeding events in association with the use of topical bovine thrombin have been limited to case reports lacking clear cause and effect relationship determination. Recent studies have failed to establish significant differences in the rates of bleeding events between those treated with bovine thrombin and those treated with either human or recombinant thrombin.
机译:背景技术在手术期间或之后最令人期待但潜在的严重并发症之一是出血事件。在与外科手术出血并发症相关的许多潜在因素中,牛凝血酶的使用已被确定为出血风险增加的可能原因。这些与局部使用牛凝血酶有关的出血事件的报告大多限于缺乏明确因果关系确定的病例报告。最近的研究未能在用牛凝血酶治疗的人和用人凝血酶或重组凝血酶的人之间确定出血事件发生率的显着差异。

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