miR-32 inhibits proliferation epithelial–mesenchymal transition and metastasis by targeting TWIST1 in non-small-cell lung cancer cells

摘要

BackgroundBy analyzing published microRNA microarray studies, miR-32 was found to be markedly reduced in non-small-cell lung cancer (NSCLC) tissues compared with that in nontumor tissues. However, little is known about its role and molecular mechanism involved in NSCLC development and progression. Here, we report the effect of miR-32 on NSCLC cell proliferation, epithelial–mesenchymal transition (EMT), and metastasis.