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The effects of prenatal metformin on obesogenic diet-induced alterations in maternal and fetal fatty acid metabolism

机译：产前二甲双胍对致肥胖饮食诱导的母体和胎儿脂肪酸代谢变化的影响

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摘要

BackgroundMaternal obesity may program the fetus and increase the susceptibility of the offspring to adult diseases. Metformin crosses the placenta and has been associated with decreased inflammation and reversal of fatty liver in obese leptin-deficient mice. We investigated the effects of metformin on maternal and fetal lipid metabolism and hepatic inflammation using a rat model of diet-induced obesity during pregnancy.

机译：背景孕妇肥胖可能会使胎儿受孕，并增加后代对成人疾病的敏感性。二甲双胍穿过胎盘，与肥胖的瘦素缺乏症小鼠的炎症减少和脂肪肝逆转有关。我们使用妊娠期饮食诱发肥胖的大鼠模型调查了二甲双胍对母体和胎儿脂质代谢和肝炎症的影响。

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期刊名称 Nutrition Metabolism
作者
Kemoy Harris; Neeraj Desai; Madhu Gupta; Xiangying Xue; Prodyot K. Chatterjee; Burton Rochelson; Christine N. Metz;
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作者单位

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年(卷),期 2016(13),1
年度 2016
页码 55
总页数 13
原文格式 PDF
正文语种
中图分类营养学;
关键词
Fatty acid metabolism Fetal programming Metabolic syndrome Pregnancy;

机译：脂肪酸代谢;胎儿程序设计;代谢综合症;怀孕;

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专利

1. Effect of maternal metabolism on fetal supply: Glucose, non-esterified fatty acids and beta-hydroxybutyrate concentrations in canine maternal serum and fetal fluids at term pregnancy [J] . Animal Reproduction Science . 2018,第期

机译：母体代谢对胎儿供给的影响：甘蔗，非酯化脂肪酸和β-羟基丁酸酯浓度在甘氨酸母体血清和妊娠期胎儿液中的浓度
2. Effects of maternal dietary omega-3 polyunsaturated fatty acids and methionine during late gestation on fetal growth,DNA methylation,and mRNA relative expression of genes associated with the inflammatory response, lipid metabolism and DNA methylation [J] . Milca Rosa Velazquez, Fernanda Batistel, Juan Manuel Pinos Rodriguez, 畜牧与生物技术杂志(英文版) . 2021,第002期

机译：母体膳食ω-3多不饱和脂肪酸和蛋氨酸在晚期妊娠期间对胎儿生长，DNA甲基化和mRNA相关基因的相对表达与炎症反应，脂质代谢和DNA甲基化相关的相对表达
3. Effects of maternal dietary omega-3 polyunsaturated fatty acids and methionine during late gestation on fetal growth,DNA methylation,and mRNA relative expression of genes associated with the inflammatory response,lipid metabolism and DNA methylation in placenta and offspring’s liver in sheep [J] . Milca Rosa Velazquez, Fernanda Batistel, Juan Manuel Pinos Rodriguez, 畜牧与生物技术杂志：英文版 . 2021,第002期

机译：母体膳食ω-3多不饱和脂肪酸和蛋氨酸在胎儿生长，DNA甲基化和mRNA相对表达中的胎儿炎症反应，脂质代谢和DNA甲基羊羊肝癌中的结晚妊娠
4. Intrahepatic Cholestasis of Pregnancy: A Placebo-controlled Randomized Trial of Ursodeoxycholic Acid Vs. Dexamethasone On Maternal and Fetal Outcome and Metabolism [C] . A. Glantz, H.-u. Marschall, F. Lammert, Falk Symposium . 2003

机译：妊娠的肝内胆汁淤积：一种安慰剂对照的核糖核酸随机试验与母亲和胎儿结果和新陈代谢的地塞米松
5. The acute effects of metformin on glucose oxidation and fatty acid metabolism in rodent skeletal muscle. [D] . Collier, Cheryl Anne. 2004

机译：二甲双胍对啮齿动物骨骼肌葡萄糖氧化和脂肪酸代谢的急性影响。
6. Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Prenatal Effects on Growth and Metabolism [O] . Ana Heras-Molina, José Luis Pesántez-Pacheco, Consolación Garcia-Contreras, 2021

机译：妊娠期间母体补充多酚和ω-3脂肪酸：对生长和新陈代谢的产前影响
7. The effects of prenatal metformin on obesogenic diet-induced alterations in maternal and fetal fatty acid metabolism [O] . Kemoy Harris, Neeraj Desai, Madhu Gupta, 2016

机译：产前二甲双胍对致肥胖饮食诱导的母体和胎儿脂肪酸代谢变化的影响

The effects of prenatal metformin on obesogenic diet-induced alterations in maternal and fetal fatty acid metabolism

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