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The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults

机译:APOB插入/缺失多态性(rs17240441)影响健康成年人的餐后血脂

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摘要

BackgroundApolipoprotein (apo)B is the structural apoprotein of intestinally- and liver- derived lipoproteins and plays an important role in the transport of triacylglycerol (TAG) and cholesterol. Previous studies have examined the association between the APOB insertion/deletion (ins/del) polymorphism (rs17240441) and postprandial lipaemia in response to a single meal; however the findings have been inconsistent with studies often underpowered to detect genotype-lipaemia associations, focused mainly on men, or with limited postprandial characterisation of participants. In the present study, using a novel sequential test meal protocol which more closely mimics habitual eating patterns, we investigated the impact of APOB ins/del polymorphism on postprandial TAG, non-esterified fatty acids, glucose and insulin levels in healthy adults.
机译:背景载脂蛋白(apo)B是肠道和肝脏来源的脂蛋白的结构载脂蛋白,在三酰甘油(TAG)和胆固醇的运输中起重要作用。先前的研究已经检查了APOB插入/缺失(ins / del)多态性(rs17240441)与餐后脂肪血症对单餐反应的关系。然而,该发现与通常不足以检测基因型-血脂关联的研究不一致,这些研究主要集中于男性,或参与者的餐后特征有限。在本研究中,我们使用一种新型的顺序测试膳食方案,该方案更接近于习惯性的饮食习惯,我们调查了APOB ins / del多态性对健康成年人餐后TAG,非酯化脂肪酸,葡萄糖和胰岛素水平的影响。

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