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Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside

机译:高血糖诱导的路易波黄酮和苯丙酮酸-2-O-β-D-葡萄糖苷对氧化应激和心脏病的心脏保护作用

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摘要

Diabetic patients are at an increased risk of developing heart failure when compared to their non-diabetic counter parts. Accumulative evidence suggests chronic hyperglycemia to be central in the development of myocardial infarction in these patients. At present, there are limited therapies aimed at specifically protecting the diabetic heart at risk from hyperglycemia-induced injury. Oxidative stress, through over production of free radical species, has been hypothesized to alter mitochondrial function and abnormally augment the activity of the NADPH oxidase enzyme system resulting in accelerated myocardial injury within a diabetic state. This has led to a dramatic increase in the exploration of plant-derived materials known to possess antioxidative properties. Several edible plants contain various natural constituents, including polyphenols that may counteract oxidative-induced tissue damage through their modulatory effects of intracellular signaling pathways. Rooibos, an indigenous South African plant, well-known for its use as herbal tea, is increasingly studied for its metabolic benefits. Prospective studies linking diet rich in polyphenols from rooibos to reduced diabetes associated cardiovascular complications have not been extensively assessed. Aspalathin, a flavonoid, and phenylpyruvic acid-2-O-β-D-glucoside, a phenolic precursor, are some of the major compounds found in rooibos that can ameliorate hyperglycemia-induced cardiomyocyte damage in vitro. While the latter has demonstrated potential to protect against cell apoptosis, the proposed mechanism of action of aspalathin is linked to its capacity to enhance the expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) expression, an intracellular antioxidant response element. Thus, here we review literature on the potential cardioprotective properties of flavonoids and a phenylpropenoic acid found in rooibos against diabetes-induced oxidative injury.
机译:与非糖尿病患者相比,糖尿病患者发生心力衰竭的风险更高。累积的证据表明,慢性高血糖在这些患者的心肌梗塞发展中起中心作用。当前,旨在特异性保护处于危险中的糖尿病心脏免于高血糖引起的损伤的疗法有限。据推测,由于自由基种类的过度产生,氧化应激会改变线粒体功能并异常增加NADPH氧化酶系统的活性,从而导致糖尿病状态下心肌的加速损伤。这导致对已知具有抗氧化特性的植物来源材料的探索急剧增加。几种可食用植物含有各种天然成分,包括可通过其对细胞内信号通路的调节作用来抵消氧化诱导的组织损伤的多酚。 Rooibos是南非的一种本土植物,以其作为凉茶而闻名,人们对其新陈代谢的益处进行了越来越多的研究。尚未广泛评估将如意宝所含的多酚饮食与减少糖尿病相关的心血管并发症联系起来的前瞻性研究。芦荟中发现了一些主要化合物,其中黄酮类化合物阿斯帕拉汀和苯酚丙酮酸-2-O-β-D-葡萄糖苷(酚类前体)可以减轻体外高血糖引起的心肌细胞损伤。虽然后者已显示出潜在的保护作用,可防止细胞凋亡,但提出的阿斯帕拉丁作用机制与其增强细胞内抗氧化剂反应元件核因子(类胡萝卜素衍生的2)样2(Nrf2)表达的能力有关。 。因此,在这里,我们回顾了关于在路易波波中发现的类黄酮和苯丙酸对糖尿病引起的氧化损伤的潜在心脏保护作用的文献。

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