2-/5-Substituted uracil-1-yl/tetrahydrofuran-5-carboxylic acids as pyrimidine nucleotide analogues

摘要

Alkylation of 2,4-bis/trimethylsilyloxy/pyrimidines with 5-chlorotetra-hydrofuran-2-carboxylic acid esters yielded 2-/5-substituted uracil-1-yl/tetrahydrofuran-5-carboxylic acid esters. The corresponding acids were synthesized by hydrolysis, and 2′,3′-dideoxynucleoside analogues - by reduction. Conformation of the compounds was studied by PMR-spectroscopy.