>Introduction: Brain metastasis from endometrial carcinoma are very rare and usually develop as part of a widespread disseminated disease. Even more rare are endometrial adenocarcinoma dural metastases. Most often is located in the cerebrum and is solitary lesion. Age, performance status of the patient and state of control of the primary disease affect the prognosis and guide treatment decisions in these patients. METHODS: A 66-year-old woman was admitted with inaugural seizures in the emergency department (ED). The patient had a history of endometrial adenocarcinoma previous submitted to surgery 3 years before, without signs of relapse. At the ED the patient had a Glasgow Coma Scale of 7 (O1V1M5), after the seizure and medication with benzodiazepines. CT-Scan and posteriorly MRI showed an expansive lesion with epicenter in the bony structures of the sphenoid triangle and roof of the left orbit, epidural extension and probable infiltration of the brain parenchyma with edema associated and consequently regional mass effect through the parenchyma and adjacent ventricular system with collapse of the frontal horn. The lesion also had an anatomical relationship with bone structures (orbital roof, frontal bone) with thickness of these structures and areas of bone erosion with some grade of compression of the ocular globe. Body CT didn’t show any lesion in other organs or systems. Differential diagnosis was intraosseous meningioma or a secondary lesion in relationship with the previous adenocarcinoma. The patient was submitted to a bone, dural and lesion biopsy with titanium cranioplasty. >Results: Histology revealed the diagnosis of metastasis of adenocarcinoma, compatible with endometrial primitive, in meningioma.The patient was studied and it was not found a primary tumor. >Conclusions: Early detection of brain metastasis in endometrial carcinoma patients is very important since brain metastasis at their early stage have a better prognosis and response to the treatment. Moreover, brain-imaging studies should be considered in the routine follow-up of patients with primary endometrial carcinoma and also to search for a primary source in females with brain metastasis of unknown primary lesion.
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