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Enrichment and Purification of Deoxyschizandrin and γ-Schizandrin from the Extract of Schisandra chinensis Fruit by Macroporous Resins

机译:大孔树脂对五味子果实提取物中脱氧五味子素和γ-五味子素的富集纯化

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摘要

In present study, the performance and separation characteristics of 21 macroporous resins for the enrichment and purification of deoxyschizandrin and γ-schizandrin, the two major lignans from Schisandra chinensis extracts, were evaluated. According to our results, HPD5000, which adsorbs by the molecular tiers model, was the best macroporous resin, offering higher adsorption and desorption capacities and higher adsorption speed for deoxyschizandrin and γ-schizandrin than other resins. Columns packed with HPD5000 resin were used to perform dynamic adsorption and desorption tests to optimize the technical parameters of the separation process. The results showed that the best adsorption time is 4 h, the rate of adsorption is 0.85 mL/min (4 BV/h) and the rate of desorption is 0.43 mL/min (2 BV/h). After elution with 90% ethanol, the purity of deoxy-schizandrin increased 12.62-fold from 0.37% to 4.67%, the purity of γ-schizandrin increased 15.8-fold from 0.65% to 10.27%, and the recovery rate was more than 80%.
机译:本研究评估了21种大孔树脂对五味子提取物中的两种主要木脂素-脱氧五味子和γ-五味子的富集和纯化的性能和分离特性。根据我们的结果,通过分子层次模型吸附的HPD5000是最好的大孔树脂,与其他树脂相比,对脱氧五味子和γ-五味子的吸附和解吸能力更高,吸附速度更快。使用装有HPD5000树脂的色谱柱进行动态吸附和解吸测试,以优化分离工艺的技术参数。结果表明,最佳吸附时间为4 h,吸附速率为0.85 mL / min(4 BV / h),解吸速率为0.43 mL / min(2 BV / h)。用90%乙醇洗脱后,脱氧五味子素的纯度从0.37%增加到4.67%的12.62倍,γ-五味子素的纯度从0.65%增加到10.27%的15.8倍,回收率超过80% 。

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