Synthesis of No-Carrier-Added 4-18FFluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide

摘要

4-[¹⁸F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[¹⁸F]fluorophenoxy moiety. In order to prepare 4-[¹⁸F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [¹⁸F]fluoride is suitable. In this paper a new, two step radiosynthesis starting from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide and [¹⁸F]fluoride with subsequent deprotection is described, yielding n.c.a. [¹⁸F]fluorophenol in 34 to 36% radiochemical yield.