A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha

摘要

A new atisane-type diterpene, ent-16α-hydroxy-atisane-3,4-lactone (>4) and three known diterpenes, ent-16α-hydroxy-atisane-3-one (>1), ent-atisane-3β,16α-diol (>2), ent-3,4-seco-16α-hydroxyatis- 4(19)-en -3-oic acid (>3) were isolated from the bark of the mangrove plant Excoecaria agallocha. Their structures and relative stereochemistry were elucidated by means of extensive NMR and MS analysis. Compound >3 exhibited significant anti-microfouling activity against the adherence of Pseudomonas pseudoalcaligenes, with an EC50 value of 0.54 ± 0.01 ppm.