Effects of Ethyl Pyruvate on Allodynia TNF-α Expression and Apoptosis in the Dorsal Root Ganglion after Spinal Nerve Ligation Injury

摘要

BackgroundIt has been demonstrated that the expression of tumor necrosis factor-α (TNF-α) and apoptotic cell death in the dorsal root ganglion (DRG) following spinal nerve constriction injury play a role in the initiation and continuation of hyperalgesia and allodynia. The present study was designed to investigate the effects of ethyl pyruvate (EP) on mechanical and cold allodynia, TNF-α expression, and apoptosis in DRG after spinal nerve ligation injury.