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Neurobehavioural Changes and Brain Oxidative Stress Induced by Acute Exposure to GSM900 Mobile Phone Radiations in Zebrafish (Danio rerio)

机译:斑马鱼GSM900手机辐射的急性暴露引起的神经行为改变和脑氧化应激。

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摘要

The impact of mobile phone (MP) radiation on the brain is of specific interest to the scientific community and warrants investigations, as MP is held close to the head. Studies on humans and rodents revealed hazards MP radiation associated such as brain tumors, impairment in cognition, hearing etc. Melatonin (MT) is an important modulator of CNS functioning and is a neural antioxidant hormone. Zebrafish has emerged as a popular model organism for CNS studies. Herein, we evaluated the impact of GSM900MP (GSM900MP) radiation exposure daily for 1 hr for 14 days with the SAR of 1.34W/Kg on neurobehavioral and oxidative stress parameters in zebrafish. Our study revealed that, GSM900MP radiation exposure, significantly decreased time spent near social stimulus zone and increased total distance travelled, in social interaction test. In the novel tank dive test, the GSM900MP radiation exposure elicited anxiety as revealed by significantly increased time spent in bottom half; freezing bouts and duration and decreased distance travelled, average velocity, and number of entries to upper half of the tank. Exposed zebrafish spent less time in the novel arm of the Y-Maze, corroborating significant impairment in learning as compared to the control group. Exposure decreased superoxide dismutase (SOD), catalase (CAT) activities whereas, increased levels of reduced glutathione (GSH) and lipid peroxidation (LPO) was encountered showing compromised antioxidant defense. Treatment with MT significantly reversed the above neurobehavioral and oxidative derangements induced by GSM900MP radiation exposure. This study traced GSM900MP radiation exposure induced neurobehavioral aberrations and alterations in brain oxidative status. Furthermore, MT proved to be a promising therapeutic candidate in ameliorating such outcomes in zebrafish.
机译:移动电话(MP)辐射对大脑的影响引起了科学界的特别关注,并且有必要进行研究,因为MP靠近头部。对人类和啮齿类动物的研究揭示了MP辐射的危害,如脑部肿瘤,认知障碍,听力受损等。褪黑激素(MT)是中枢神经系统功能的重要调节剂,是一种神经抗氧化剂。斑马鱼已经成为中枢神经系统研究的流行模型生物。本文中,我们评估了GSM900MP(GSM900MP)每天辐射1小时,持续14天,SAR为1.34W / Kg对斑马鱼神经行为和氧化应激参数的影响。我们的研究表明,在社交互动测试中,GSM900MP辐射暴露,显着减少了在社会刺激区附近的停留时间并增加了旅行的总距离。在新型的油箱潜水测试中,GSM900MP的辐射暴露引起焦虑,而下半部的时间显着增加表明了这一点。结冰的回响和持续时间以及减少的行进距离,平均速度和进入水箱上半部分的次数。暴露的斑马鱼在Y型迷宫的新臂上花费的时间更少,与对照组相比,证实了学习上的重大障碍。暴露降低了超氧化物歧化酶(SOD),过氧化氢酶(CAT)的活性,而还原谷胱甘肽(GSH)和脂质过氧化(LPO)的水平升高,表明抗氧化防御能力受损。 MT治疗显着逆转了上述由GSM900MP辐射引起的神经行为和氧化紊乱。这项研究追踪了GSM900MP辐射暴露引起的神经行为异常和大脑氧化状态的改变。此外,MT被证明是改善斑马鱼结果的有前途的治疗候选者。

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