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The Prioritization of Clinical Risk Factors of Obstructive Sleep Apnea Severity Using Fuzzy Analytic Hierarchy Process

机译:应用模糊层次分析法确定阻塞性睡眠呼吸暂停严重程度的临床危险因素

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摘要

Recently, there has been a problem of shortage of sleep laboratories that can accommodate the patients in a timely manner. Delayed diagnosis and treatment may lead to worse outcomes particularly in patients with severe obstructive sleep apnea (OSA). For this reason, the prioritization in polysomnography (PSG) queueing should be endorsed based on disease severity. To date, there have been conflicting data whether clinical information can predict OSA severity. The 1,042 suspected OSA patients underwent diagnostic PSG study at Siriraj Sleep Center during 2010-2011. A total of 113 variables were obtained from sleep questionnaires and anthropometric measurements. The 19 groups of clinical risk factors consisting of 42 variables were categorized into each OSA severity. This study aimed to array these factors by employing Fuzzy Analytic Hierarchy Process approach based on normalized weight vector. The results revealed that the first rank of clinical risk factors in Severe, Moderate, Mild, and No OSA was nighttime symptoms. The overall sensitivity/specificity of the approach to these groups was 92.32%/91.76%, 89.52%/88.18%, 91.08%/84.58%, and 96.49%/81.23%, respectively. We propose that the urgent PSG appointment should include clinical risk factors of Severe OSA group. In addition, the screening for Mild from No OSA patients in sleep center setting using symptoms during sleep is also recommended (sensitivity = 87.12% and specificity = 72.22%).
机译:最近,存在睡眠实验室不足的问题,该实验室无法及时容纳患者。延迟的诊断和治疗可能会导致更糟的结果,特别是在患有严重阻塞性睡眠呼吸暂停(OSA)的患者中。因此,应根据疾病的严重程度认可多导睡眠图(PSG)排队的优先级。迄今为止,关于临床信息是否可以预测OSA严重程度的数据存在争议。 2010-2011年期间,对1,042名可疑OSA患者进行了Siriraj睡眠中心诊断性PSG研究。从睡眠问卷和人体测量学中总共获得了113个变量。将由42个变量组成的19组临床危险因素分为每种OSA严重程度。本研究旨在通过基于归一化权重向量的模糊层次分析法来排列这些因素。结果表明,夜间症状是严重,中度,轻度和无OSA的临床危险因素中的第一位。这些方法对这些组的总体敏感性/特异性分别为92.32%/ 91.76%,89.52%/ 88.18%,91.08%/ 84.58%和96.49%/ 81.23%。我们建议PSG的紧急任命应包括严重OSA组的临床危险因素。此外,还建议在睡眠中心使用睡眠期间症状对无OSA患者进行轻度筛查(敏感性= 87.12%,特异性= 72.22%)。

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