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Targeted and synergistic therapy for hepatocellular carcinoma: monosaccharide modified lipid nanoparticles for the co-delivery of doxorubicin and sorafenib

机译：肝细胞癌的靶向协同治疗：阿糖修饰的脂质纳米粒用于阿霉素和索拉非尼的共同给药

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PurposeTargeted hepatocellular carcinoma therapy was carried out to improve the efficacy of liver cancer treatment. The purpose of this study was to design an N-acetylgalactosamine (NAcGal) modified and pH sensitive doxorubicin (DOX) prodrug (NAcGal-DOX) for the construction of lipid nanoparticles (LNPs).

机译：目的进行靶向肝细胞癌治疗以提高肝癌治疗的疗效。这项研究的目的是设计一种N-乙酰半乳糖胺（NAcGal）修饰的和pH敏感的阿霉素（DOX）前药（NAcGal-DOX），用于构建脂质纳米颗粒（LNP）。

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期刊名称 Drug Design Development and Therapy
作者
Wendu Duan; Yan Liu;
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作者单位

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年(卷),期 2018(12),-1
年度 2018
页码 2149–2161
总页数 13
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
hepatocellular carcinoma asialoglycoprotein receptor N-acetylgalactosamine pH sensitive prodrug;

机译：肝细胞癌;去唾液酸糖蛋白受体;N-乙酰半乳糖胺;pH敏感;前药;

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专利

1. Targeted and synergistic therapy for hepatocellular carcinoma: monosaccharide modified lipid nanoparticles for the co-delivery of doxorubicin and sorafenib [J] . Wendu Duan, Yan Liu Drug Design, Development and Therapy . 2018,第InaProgress期

机译：肝细胞癌的靶向和协同治疗：阿糖修饰的脂质纳米颗粒用于阿霉素和索拉非尼的共同给药
2. Ultrasound-Triggered Nanodroplets for Targeted Co-Delivery of Sorafenib/Doxorubicin for Hepatocellular Carcinoma Therapy [J] . Tan Yang, Xu Ming, Liu Jie, Journal of biomedical nanotechnology . 2019,第9期

机译：用于肝细胞癌治疗的索拉烯纤维素/多柔比星的靶向共同递送超声触发的纳米辊
3. Targeted Therapy for Hepatocellular Carcinoma: Co-Delivery of Sorafenib and Curcumin Using Lactosylated pH-Responsive Nanoparticles [J] . Yun Bian, Dong Guo Drug Design, Development and Therapy . 2020,第1期

机译：用于肝细胞癌的靶向治疗：使用乳糖基化的pH-响应纳米颗粒共同递送Sorafenib和姜黄素
4. Magnetically Targeted Delivery of Sorafenib Through Magnetic Solid Lipid Nanoparticles Towards Treatment of Hepatocellular Carcinoma [C] . F. Vischio, N. Depalo, R. M. Iacobazzi, NATO Advanced Study Institute on Detection, Diagnosis and Health Concerns of Toxic Chemical and Biological Agents . 2020

机译：通过磁性固体脂质纳米粒子致磁性固体脂质纳米粒子对肝细胞癌治疗的磁性靶向递送
5. Poly(lactide-co-glycolide) Microspheres for Localized, Magnetic Resonance Imaging Monitored, Transcatheter Delivery of Sorafenib to Hepatocellular Carcinoma. [D] . Chen, Jeane. 2015

机译：聚（丙交酯-共-乙交酯）微球体用于局部监测，磁共振成像监测，索拉非尼经导管输送至肝细胞癌。
6. Targeted Therapy for Hepatocellular Carcinoma: Co-Delivery of Sorafenib and Curcumin Using Lactosylated pH-Responsive Nanoparticles [O] . Yun Bian, Dong Guo 2020

机译：肝细胞癌的靶向治疗：索拉非尼和姜黄素使用乳糖基化的pH响应性纳米颗粒的共同递送
7. Targeted and synergistic therapy for hepatocellular carcinoma: monosaccharide modified lipid nanoparticles for the co-delivery of doxorubicin and sorafenib [O] . Wendu Duan, Yan Liu 2018

机译：针对肝细胞癌的靶向和协同疗法：单糖修饰的脂质纳米粒子用于多柔比星和索拉非尼的共递送

Targeted and synergistic therapy for hepatocellular carcinoma: monosaccharide modified lipid nanoparticles for the co-delivery of doxorubicin and sorafenib

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