The sequence of 165 nucleotides at the 3' end of the 1D (VP1) gene of foot-and-mouth disease (FMD) virus was determined for 44 type Asia 1 strains isolated from throughout Asia between 1954-92. Analysis of the relationships between the virus genomes showed epidemiological links not previously evident. The possible origin of the only outbreak of FMD Asia 1 to have occurred in Europe, in Greece in 1984, was identified because the nucleotide sequence of this virus was closely-related to the sequences of those present in the Middle East between 1983-5. Variation in the region sequenced was not as great as that seen in the other FMDV serotypes and all viruses shared greater than 85% nucleotide identity. Thus all the virus isolates examined were considered to belong to a single genotype. A database of Asia 1 virus sequences has been established which will facilitate the rapid analysis of new outbreaks strains.
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机译：对于1954-92年间从整个亚洲分离出的44种亚洲1型菌株，确定了口蹄疫（FMD）病毒1D（VP1）基因3'末端165个核苷酸的序列。对病毒基因组之间关系的分析表明，以前没有发现流行病学联系。由于该病毒的核苷酸序列与1983-5年间中东地区存在的序列密切相关，因此确定了可能于1984年在欧洲发生于希腊的FMD Asia 1的唯一爆发。测序区域的变异不如其他FMDV血清型所见，所有病毒均具有大于85％的核苷酸同一性。因此，所有检查的病毒分离株都被认为属于单一基因型。建立了亚洲1病毒序列数据库，这将有助于快速分析新的暴发菌株。
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