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Computational models of basal-ganglia pathway functions: focus on functional neuroanatomy

机译:基底神经节通路功能的计算模型:专注于功能神经解剖

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摘要

Over the past 15 years, computational models have had a considerable impact on basal-ganglia research. Most of these models implement multiple distinct basal-ganglia pathways and assume them to fulfill different functions. As there is now a multitude of different models, it has become complex to keep track of their various, sometimes just marginally different assumptions on pathway functions. Moreover, it has become a challenge to oversee to what extent individual assumptions are corroborated or challenged by empirical data. Focusing on computational, but also considering non-computational models, we review influential concepts of pathway functions and show to what extent they are compatible with or contradict each other. Moreover, we outline how empirical evidence favors or challenges specific model assumptions and propose experiments that allow testing assumptions against each other.
机译:在过去的15年中,计算模型对基底神经节研究产生了重大影响。这些模型中的大多数都实现了多种不同的基底神经节通路,并假定它们履行了不同的功能。由于现在存在多种不同的模型,因此要跟踪它们的各种功能(有时只是对路径功能的假设稍有不同),就变得很复杂。此外,监督经验数据在多大程度上证实或质疑各个假设已成为挑战。着重于计算,但也考虑非计算模型,我们回顾了影响途径功能的概念,并表明它们在何种程度上相互兼容或矛盾。此外,我们概述了经验证据如何支持或挑战特定的模型假设,并提出了允许相互检验假设的实验。

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