Semantic phonologic and verb fluency in Huntington’sdisease

摘要

Verbal fluency tasks have been identified as important indicators of executive functioning impairment in patients with frontal lobe dysfunction. Although the usual evaluation of this ability considers phonologic and semantic criteria, there is some evidence that fluency of verbs would be more sensitive in disclosing frontostriatal physiopathology since frontal regions primarily mediate retrieval of verbs. Huntington’s disease usually affects these circuitries.ObjectiveTo compare three types of verbal fluency task in the assessment of frontal-striatal dysfunction in HD subjects.