Microbial Agents as Putative Inducers of B Cell Lymphoma in Sjögrens Syndrome through an Impaired Epigenetic Control: The State-of-The-Art

摘要

Introduction Understanding the mechanisms underlying the pathogenesis of Sjögren's syndrome (SS) is crucially important in order to be able to discriminate the steps that lead to B cell transformation and promptly identify the patients at risk of lymphomagenesis. The aim of this narrative review is to describe the evidence concerning the role that infections or dysbiosis plays in the epigenetic control of gene expression in SS patients and their possible involvement in B cell lymphomagenesis.