Verapamil- and state-dependent effect of 2-aminoethylmethanethiosulphonate (MTSEA) on hKv1.3 channels

摘要

BACKGROUND AND PURPOSET-cells usually express voltage-gated Kv1.3 channels. These channels are distinguished by their typical C-type inactivation. Therefore, to be able to rationally design drugs specific for the C-type inactivation state that may have therapeutic value in autoimmune disease therapy, it is necessary to identify those amino acids that are accessible for drug binding in C-type inactivated channels.