Prostaglandin E2 induces contraction of liver myofibroblasts by activating EP3 and FP prostanoid receptors

摘要

Background and purpose:Increased portal pressure in liver injury results from hypercontraction of perivascular non-parenchymal cells including liver myofibroblasts (MFs). Prostaglandin E2 (PGE2) is the major eicosanoid which is released around the venous system during liver injury, but little is known about their contractile effect on MFs.