Synergistic vascular protective effects of combined low doses of PPARα and PPARγ activators in angiotensin II-induced hypertension in rats

摘要

Background and Purpose:Protective cardiovascular effects of peroxisome proliferator activated receptor (PPAR)α and PPARγ activators have been demonstrated. If used as vasoprotective agents in high risk vascular patients rather than for their metabolic benefits, these agents could be associated with unwanted side effects. As a proof of concept to support the use of combined low doses of PPARα and PPARγ as vascular protective agents in high risk vascular patients, we tested the hypothesis that combined low doses of PPARα (fenofibrate) and PPARγ (rosiglitazone) activators would provide vascular protective benefits similar to full individual doses of these PPAR agonists.