Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases

摘要

Background and purpose:ARL 67156, 6-N,N-Diethyl-D-β-γ-dibromomethylene adenosine triphosphate, originally named FPL 67156, is the only commercially available inhibitor of ecto-ATPases. Since the first report on this molecule, various ectonucleotidases responsible for the hydrolysis of ATP at the cell surface have been cloned and characterized. In this work, we identified the ectonucleotidases inhibited by ARL 67156.