The distribution of tritium-labelled prostaglandin E1 injected in amounts sufficient to produce central nervous effects in cats and chicks

摘要

1. After injection of tritiated prostaglandin E1 into the lateral cerebral ventricle, the carotid and vertebral arteries and the aorta in cats, only a small proportion of the radioactivity was recovered from the central nervous system.2. Similar results were obtained when the prostaglandin was given intra-venously and intra-arterially to chicks.3. The results of this study confirm work in other species (Hansson & Samuelsson, 1965; Samuelsson, 1964, 1965) and suggest that prostaglandin E1 exerts its central pharmacological actions in small concentrations.