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Extended report: Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis

机译：扩展的报告：阻断原肌球蛋白受体激酶A（TrkA）受体可在两种骨关节炎大鼠模型中抑制疼痛行为

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摘要

ObjectivesTropomyosin receptor kinase A (TrkA) mediates nociceptor sensitisation by nerve growth factor (NGF), but it is unknown whether selective TrkA inhibition will be an effective strategy for treating osteoarthritis (OA) pain. We determined the effects of a TrkA inhibitor (AR786) on pain behaviour, synovitis and joint pathology in two rat OA models.

机译：目的Tropomyosin受体激酶A（TrkA）通过神经生长因子（NGF）介导伤害感受器敏化作用，但尚不清楚选择性抑制TrkA是否将是治疗骨关节炎（OA）疼痛的有效策略。我们确定了两种大鼠OA模型中TrkA抑制剂（AR786）对疼痛行为，滑膜炎和关节病理的影响。

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期刊名称 BMJ Open Access
作者
Lilian N Nwosu; Paul I Mapp; Victoria Chapman; David A Walsh;
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作者单位

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年(卷),期 -1(75),6
年度 -1
页码 1246–1254
总页数 9
原文格式 PDF
正文语种
中图分类
关键词
Analgesics Knee Osteoarthritis Synovitis Treatment;

机译：镇痛药;膝骨关节炎;滑膜炎;治疗;

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专利

1. Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis [J] . Nwosu Lilian N., Mapp Paul I., Chapman Victoria, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2016,第6期

机译：阻断原肌球蛋白受体激酶A（TrkA）受体可在两种骨关节炎大鼠模型中抑制疼痛行为
2. Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis [J] . Sadaf Ashraf, Karyn S. Bouhana, Jed Pheneger, Arthritis Research . 2016,第1期

机译：选择性抑制原肌球蛋白受体激酶A（TrkA）可减轻两种炎性关节炎大鼠的疼痛和关节损伤
3. Blockage of tropomyosin receptor kinase a (TrkA) enhances chemo-sensitivity in breast cancer cells and inhibits metastasis in vivo [J] . Ju Zhang, Lun-Shan Wang, Shu-Lai Ye, International Journal of Clinical and Experimental Medicine . 2015,第1期

机译：原肌球蛋白受体激酶a（TrkA）的阻断增强了乳腺癌细胞的化学敏感性并抑制了体内转移
4. G PROTEIN-COUPLED RECEPTOR KINASE TYPE 4 (GRK4) GENE VARIANTS AND RESPONSE TO ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKER THERAPY [C] . Hironobu Sanada, Junichi Yatabe, Midori Sasaki Yatabe, 9th International Symposium on Salt(第九届世界盐业大会）论文集 . 2009

机译：G蛋白偶联的4型受体激酶（GRK4）基因变异和对血管紧张素II 1型受体阻滞剂的反应
5. The multi-targeted receptor tyrosine kinase inhibitor, linifanib (ABT-869), induces apoptosis and inhibits proliferation of leukemia cells through phosphoinositide-3 kinase (PI3K)/AKT-dependent signaling pathways. [D] . Hernandez, Jenny Elizabeth. 2010

机译：多靶点受体酪氨酸激酶抑制剂利尼法尼（ABT-869）通过磷酸肌醇3激酶（PI3K）/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
6. Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis [O] . Sadaf Ashraf, Karyn S. Bouhana, Jed Pheneger, 2016

机译：选择性抑制原肌球蛋白受体激酶A（TrkA）可减轻两种炎性关节炎大鼠模型的疼痛和关节损伤
7. Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis [O] . Nwosu Lilian Ngozi, Mapp Paul I., Chapman Victoria, 2015

机译：阻断原肌球蛋白受体激酶A（TrkA）受体可在两种骨关节炎大鼠模型中抑制疼痛行为

Extended report: Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis

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