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  • 1.

    【2hr】What the future holds for Biomedical Engineering Online?

    包量

    机译 在线生物医学工程的未来将如何发展？
    摘要：The future of biomedical engineering is exciting, and prospects for biomedical engineering journals are rapidly growing. In this editorial, a brief history of Biomedical Engineering Online is outlined, along with our plans for future directions of the journal.
  • 2.

    【2hr】Novel dynamic corneal response parameters in a practice use: a critical review

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    机译 在实践中使用新型动态角膜反应参数：严格审查。
    摘要：BackgroundNon-contact tonometers based on the method using air puff and Scheimpflug’s fast camera are one of the latest devices allowing the measurement of intraocular pressure and additional biomechanical parameters of the cornea. Biomechanical features significantly affect changes in intraocular pressure values, as well as their changes, may indicate the possibility of corneal ectasia. This work presents the latest and already known biomechanical parameters available in the new offered software. The authors focused on their practical application and the diagnostic credibility indicated in the literature.
  • 3.

    【2hr】Processing of collagen based biomaterials and the resulting materials properties

    包量

    机译 胶原基生物材料的加工及其材料性能
    • 作者：Michael Meyer
    • 刊名：BioMedical Engineering OnLine
    • 2019年第期
    摘要：Collagen, the most abundant extracellular matrix protein in animal kingdom belongs to a family of fibrous proteins, which transfer load in tissues and which provide a highly biocompatible environment for cells. This high biocompatibility makes collagen a perfect biomaterial for implantable medical products and scaffolds for in vitro testing systems. To manufacture collagen based solutions, porous sponges, membranes and threads for surgical and dental purposes or cell culture matrices, collagen rich tissues as skin and tendon of mammals are intensively processed by physical and chemical means. Other tissues such as pericardium and intestine are more gently decellularized while maintaining their complex collagenous architectures. Tissue processing technologies are organized as a series of steps, which are combined in different ways to manufacture structurally versatile materials with varying properties in strength, stability against temperature and enzymatic degradation and cellular response. Complex structures are achieved by combined technologies. Different drying techniques are performed with sterilisation steps and the preparation of porous structures simultaneously. Chemical crosslinking is combined with casting steps as spinning, moulding or additive manufacturing techniques. Important progress is expected by using collagen based bio-inks, which can be formed into 3D structures and combined with live cells. This review will give an overview of the technological principles of processing collagen rich tissues down to collagen hydrolysates and the methods to rebuild differently shaped products. The effects of the processing steps on the final materials properties are discussed especially with regard to the thermal and the physical properties and the susceptibility to enzymatic degradation. These properties are key features for biological and clinical application, handling and metabolization.
  • 4.

    【2hr】Combining continuous glucose monitoring and insulin pumps to automatically tune the basal insulin infusion in diabetes therapy: a review

    包量

    机译 结合连续血糖监测和胰岛素泵自动调整糖尿病治疗中基础胰岛素的输注
    摘要：For individuals affected by Type 1 diabetes (T1D), a chronic disease in which the pancreas does not produce any insulin, maintaining the blood glucose (BG) concentration as much as possible within the safety range (70–180 mg/dl) allows avoiding short- and long-term complications. The tuning of exogenous insulin infusion can be difficult, especially because of the inter- and intra-day variability of physiological and behavioral factors. Continuous glucose monitoring (CGM) sensors, which monitor glucose concentration in the subcutaneous tissue almost continuously, allowed improving the detection of critical hypo- and hyper-glycemic episodes. Moreover, their integration with insulin pumps for continuous subcutaneous insulin infusion allowed developing algorithms that automatically tune insulin dosing based on CGM measurements in order to mitigate the incidence of critical episodes. In this work, we aim at reviewing the literature on methods for CGM-based automatic attenuation or suspension of basal insulin with a focus on algorithms, their implementation in commercial devices and clinical evidence of their effectiveness and safety.
  • 5.

    【2hr】A review on low-dimensional physics-based models of systemic arteries: application to estimation of central aortic pressure

    包量

    机译 基于低维物理学的系统性动脉模型的综述：在中央主动脉压力估计中的应用
    摘要：The physiological processes and mechanisms of an arterial system are complex and subtle. Physics-based models have been proven to be a very useful tool to simulate actual physiological behavior of the arteries. The current physics-based models include high-dimensional models (2D and 3D models) and low-dimensional models (0D, 1D and tube-load models). High-dimensional models can describe the local hemodynamic information of arteries in detail. With regard to an exact model of the whole arterial system, a high-dimensional model is computationally impracticable since the complex geometry, viscosity or elastic properties and complex vectorial output need to be provided. For low-dimensional models, the structure, centerline and viscosity or elastic properties only need to be provided. Therefore, low-dimensional modeling with lower computational costs might be a more applicable approach to represent hemodynamic properties of the entire arterial system and these three types of low-dimensional models have been extensively used in the study of cardiovascular dynamics. In recent decades, application of physics-based models to estimate central aortic pressure has attracted increasing interest. However, to our best knowledge, there has been few review paper about reconstruction of central aortic pressure using these physics-based models. In this paper, three types of low-dimensional physical models (0D, 1D and tube-load models) of systemic arteries are reviewed, the application of three types of models on estimation of central aortic pressure is taken as an example to discuss their advantages and disadvantages, and the proper choice of models for specific researches and applications are advised.
  • 6.

    【2hr】Imaging modalities to diagnose carotid artery stenosis: progress and prospect

    包量

    机译 诊断颈动脉狭窄的影像学方法：进展与展望
    摘要：In the past few decades, imaging has been developed to a high level of sophistication. Improvements from one-dimension (1D) to 2D images, and from 2D images to 3D models, have revolutionized the field of imaging. This not only helps in diagnosing various critical and fatal diseases in the early stages but also contributes to making informed clinical decisions on the follow-up treatment profile. Carotid artery stenosis (CAS) may potentially cause debilitating stroke, and its accurate early detection is therefore important. In this paper, the technical development of various CAS diagnosis imaging modalities and its impact on the clinical efficacy is thoroughly reviewed. These imaging modalities include duplex ultrasound (DUS), computed tomography angiography (CTA) and magnetic resonance angiography (MRA). For each of the imaging modalities considered, imaging methodology (principle), critical imaging parameters, and the extent of imaging the vulnerable plaque are discussed. DUS is usually the initial recommended CAS diagnostic examination. However, for the therapeutic intervention, either MRA or CTA is recommended for confirmation, and for added information on intracranial cerebral circulation and aortic arch condition for procedural planning. Over the past few decades, the focus of CAS diagnosis has also shifted from pure stenosis quantification to plaque characterization. This has led to further advancement in the existing imaging tools and development of other potential imaging tools like Optical coherence tomography (OCT), photoacoustic tomography (PAT), and infrared (IR) thermography.
  • 7.

    【2hr】EZ Entropy: a software application for the entropy analysis of physiological time-series

    包量

    机译 EZ Entropy：用于生理时间序列熵分析的软件应用程序
    • 作者：Peng Li
    • 刊名：BioMedical Engineering OnLine
    • 2019年第期
    摘要：BackgroundEntropy analysis has been attracting increasing attentions in the recent two or three decades. It assesses complexity, or irregularity, of time-series which is extraordinarily relevant to physiology and diseases as demonstrated by tremendous studies. However, the complexity can hardly be appreciated by traditional methods including time-, frequency-domain analysis, and time-frequency analysis that are the common built-in options in commercialized measurement and statistical software. To facilitate the entropy analysis of physiological time-series, a new software application, namely EZ Entropy, was developed and introduced in this article.
  • 8.

    【2hr】A compact pulsatile simulator based on cam-follower mechanism for generating radial pulse waveforms

    包量

    机译 基于凸轮跟随机构的紧凑型脉动模拟器，用于产生径向脉冲波形
    摘要：BackgroundThere exists a growing need for a cost-effective, reliable, and portable pulsation simulator that can generate a wide variety of pulses depending on age and cardiovascular disease. For constructing compact pulsation simulator, this study proposes to use a pneumatic actuator based on cam-follower mechanism controlled by a DC motor. The simulator is intended to generate pulse waveforms for a range of pulse pressures and heart beats that are realistic to human blood pulsations.
  • 9.

    【2hr】Segmentation of lung parenchyma in CT images using CNN trained with the clustering algorithm generated dataset

    包量

    机译 使用由聚类算法生成的数据集训练的CNN分割CT图像中的肺实质
    摘要：BackgroundLung segmentation constitutes a critical procedure for any clinical-decision supporting system aimed to improve the early diagnosis and treatment of lung diseases. Abnormal lungs mainly include lung parenchyma with commonalities on CT images across subjects, diseases and CT scanners, and lung lesions presenting various appearances. Segmentation of lung parenchyma can help locate and analyze the neighboring lesions, but is not well studied in the framework of machine learning.
  • 10.

    【2hr】Myoelectric control algorithm for robot-assisted therapy: a hardware-in-the-loop simulation study

    包量

    机译 机器人辅助治疗的肌电控制算法：硬件在环仿真研究
    摘要：BackgroundA direct blow to the knee is one way to injure the anterior cruciate ligament (ACL), e.g., during a football or traffic accident. Robot-assisted therapy (RAT) rehabilitation, simulating regular walking, improves walking and balance abilities, and extensor strength after ACL reconstruction. However, there is a need to perform RAT during other phases of ACL injury rehabilitation before attempting an advanced exercise such as walking. This paper aims to propose a myoelectric control (MEC) algorithm for a robot-assisted rehabilitation system, “Nukawa”, to assist knee movement during these types of exercises, i.e., such as in active-assisted extension exercises.
  • 11.

    【2hr】Biomechanical analysis of different dynamic sitting techniques: an exploratory study

    包量

    机译 不同动态坐姿技术的生物力学分析：探索性研究
    摘要：Prolonged static sitting in wheelchairs increases the risk of pressure ulcers. This exploratory study proposed three dynamic sitting techniques in order to reduce the risk of developing pressure ulcer during wheelchair sitting, namely lumbar prominent dynamic sitting, femur upward dynamic sitting, and lumbar prominent with femur upward dynamic sitting. The purpose of this study was to analyze the biomechanical effects of these three techniques on interface pressure. 15 able-bodied people were recruited as subjects to compare the aforementioned sitting techniques in a random order. All parameters, including dynamic contact area, dynamic average pressure, and dynamic peak pressure on backrest and seat were measured and compared. In result, when compared with lumbar prominent dynamic sitting, femur upward dynamic sitting and lumbar prominent with femur upward dynamic sitting appeared to yield significantly lower dynamic average and peak pressure on the back part of seat, and significantly higher dynamic average and peak pressure on the front part of seat. This study can serve as a reference point for clinical physicians or wheelchair users to identify a suitable dynamic sitting technique.
  • 12.

    【2hr】Hippocampal subfields segmentation in brain MR images using generative adversarial networks

    包量

    机译 使用生成对抗网络对大脑MR图像中的海马亚域进行分割
    摘要：BackgroundSegmenting the hippocampal subfields accurately from brain magnetic resonance (MR) images is a challenging task in medical image analysis. Due to the small structural size and the morphological complexity of the hippocampal subfields, the traditional segmentation methods are hard to obtain the ideal segmentation result.
  • 13.

    【2hr】Detection of pulmonary ground-glass opacity based on deep learning computer artificial intelligence

    包量

    机译 基于深度学习计算机人工智能的肺毛玻璃样浊度检测
    摘要：BackgroundA deep learning computer artificial intelligence system is helpful for early identification of ground glass opacities (GGOs).
  • 14.

    【2hr】Plane wave imaging combined with eigenspace-based minimum variance beamforming using a ring array in ultrasound computed tomography

    包量

    机译 平面波成像结合基于特征空间的最小方差波束形成，在超声计算机断层摄影中使用环形阵列
    摘要：BackgroundUltrasound computed tomography (USCT) is usually realized with a ring array. It can provide better imaging performance and more tissue information by emitting and receiving the ultrasound signal in different directions simultaneously. However, USCT imaging is usually applied with the synthetic aperture (SA) emission method, which leads to a long scanning time with a large number of elements on the ring array. The echo image can provide the structural information, and has a higher resolution than maps of other parameters in USCT. Hence, we proposed plane wave (PW) imaging for ring array to acquire the echo wave and reduce the scanning time considerably.
  • 15.

    【2hr】Two-stage CNNs for computerized BI-RADS categorization in breast ultrasound images

    包量

    机译 乳房超声图像中计算机化BI-RADS分类的两阶段CNN
    摘要：BackgroundQuantizing the Breast Imaging Reporting and Data System (BI-RADS) criteria into different categories with the single ultrasound modality has always been a challenge. To achieve this, we proposed a two-stage grading system to automatically evaluate breast tumors from ultrasound images into five categories based on convolutional neural networks (CNNs).
  • 16.

    【2hr】Potential biomarkers of acute myocardial infarction based on weighted gene co-expression network analysis

    包量

    机译 基于加权基因共表达网络分析的急性心肌梗死潜在生物标志物
    摘要：BackgroundAcute myocardial infarction (AMI) is the common cause of mortality in developed countries. The feasibility of whole-genome gene expression analysis to identify outcome-related genes and dysregulated pathways remains unknown. Molecular marker such as BNP, CRP and other serum inflammatory markers have got the notice at this point. However, these biomarkers exhibit elevated levels in patients with thyroid disease, renal failure and congestive heart failure. In this study, three groups of microarray data sets (GES66360, , ) were collected from GEO, a total of 99, 52 and 55 samples, respectively. Weighted gene co-expression network analysis (WGCNA) was performed to obtain a classifier which composed of related genes that best characterize the AMI.
  • 17.

    【2hr】Finite state machine implementation for left ventricle modeling and control

    包量

    机译 左心室建模和控制的有限状态机实现
    摘要：BackgroundSimulation of a left ventricle has become a critical facet of evaluating therapies and operations that interact with cardiac performance. The ability to simulate a wide range of possible conditions, changes in cardiac performance, and production of nuisances at transition points enables evaluation of precision medicine concepts that are designed to function through this spectrum. Ventricle models have historically been based on biomechanical analysis, with model architectures constituted of continuous states and not conducive to deterministic processing. Producing a finite-state machine governance of a left ventricle model would enable a broad range of applications: physiological controller development, experimental left ventricle control, and high throughput simulations of left ventricle function.
  • 18.

    【2hr】Docetaxel-loaded human serum albumin (HSA) nanoparticles: synthesis, characterization, and evaluation

    包量

    机译 装载多西紫杉醇的人血清白蛋白（HSA）纳米颗粒：合成，表征和评估
    摘要：BackgroundDocetaxel (DTX) is an anticancer drug that is currently formulated with polysorbate 80 and ethanol (50:50, v/v) in clinical use. Unfortunately, this formulation causes hypersensitivity reactions, leading to severe side-effects, which have been primarily attributed to polysorbate 80.
  • 19.

    【2hr】Partial volume correction for arterial spin labeling using the inherent perfusion information of multiple measurements

    包量

    机译 使用多次测量的固有灌注信息校正动脉旋转标签的部分体积
    摘要：BackgroundArterial spin labeling (ASL) provides a noninvasive way to measure cerebral blood flow (CBF). The CBF estimation from ASL is heavily contaminated by noise and the partial volume (PV) effect. The multiple measurements of perfusion signals in the ASL sequence are generally acquired and were averaged to suppress the noise. To correct the PV effect, several methods were proposed, but they were all performed directly on the averaged image, thereby ignoring the inherent perfusion information of mixed tissues that are embedded in multiple measurements. The aim of the present study is to correct the PV effect of ASL sequence using the inherent perfusion information in the multiple measurements.
  • 20.

    【2hr】My Diabetes My Way: supporting online diabetes self-management: progress and analysis from 2016

    包量

    机译 我的糖尿病我的方式：支持在线糖尿病自我管理：2016年以来的进展和分析
    摘要：BackgroundMy Diabetes My Way (MDMW) is the National Health Service (NHS) Scotland website for people with diabetes and their carers. It consists of an interactive information website and an electronic personal health record (ePHR) available to the 291,981 people with diabetes in Scotland. We aimed to analyse the demographic characteristics of current registrants and system usage and activity during 2016.
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