Predicting drug-induced transcriptome responses of a wide range of human cell lines by a novel tensor-train decomposition algorithm

摘要

MotivationGenome-wide identification of the transcriptomic responses of human cell lines to drug treatments is a challenging issue in medical and pharmaceutical research. However, drug-induced gene expression profiles are largely unknown and unobserved for all combinations of drugs and human cell lines, which is a serious obstacle in practical applications.