In vitro Drug Metabolism Investigation of 7-Ethoxycoumarin in Human Monkey Dog and Rat Hepatocytes by High Resolution LC-MS/MS

摘要

Background: Recently, it has been an increasing concern on the bioactivation and adverse re-actions associated with consumption of herbal and nature products. 7-Ethoxycoumarin is one of coumarin family compounds, but little information is available regarding its potential reactive metabolites.