MechanisticInsight into the Photoredox Catalysisof Anti-Markovnikov Alkene Hydrofunctionalization Reactions

摘要

We describe our efforts to understand the key mechanistic aspects of the previously reported alkene hydrofunctionalization reactions using 9-mesityl-10-methylacridinium (>Mes-Acr^>+) as a photoredox catalyst. Importantly, we are able to detect alkene cation radical intermediates, and confirm that phenylthiyl radical is capable of oxidizing the persistent acridinyl radical in a fast process that unites the catalytic activity of the photoredox and hydrogen atom transfer (HAT) manifolds. Additionally, we present evidence that diphenyl disulfide ((>PhS)2) operates on a common catalytic cycle with thiophenol (>PhSH) by way of photolytic cleaveage of the disulfide bond. Transition structure analysis of the HAT step using DFT reveals that the activation barrier for H atom donation from >PhSH is significantly lower than 2-phenylmalononitrile (>PMN) due to structural reorganization. In the early stages of the reaction, >Mes-Acr^>+ is observed to engage in off-cycle adduct formation, presumably as buildup of >PhS⁻ becomes significant. The kinetic differences between >PhSH and (>PhS)2 as HAT catalysts indicate that the proton transfer step may have significant rate limiting influence.