尿脱氧吡啶啉检测在肺癌骨转移诊断与治疗评估中的意义

摘要

目的 探讨尿脱氧吡啶啉(urine Deoxypryidinoline,uDPD)在肺癌骨转移诊断和治疗评估中的意义.方法 202例肺癌患者,进行uDPD/尿肌酐(uDPD/Cr)检测,计算其在肺癌骨转移诊断中的灵敏度、特异度.55例肺癌骨转移患者分别采用二磷酸盐制剂博宁、化疗治疗,2周后复查uDPD/Cr,分别进行治疗前后比较.结果 uDPD/Cr诊断肺癌骨转移的灵敏度、特异度分别为81.4%和70.0%.25例肺癌骨转移患者博宁治疗前uDPD/Cr为(13.37±2.65) nmol/ mmol,治疗后uDPD/Cr下降为(7.34±2.15)nmol/ mmol,差异有统计学意义(P＜0.01);30例肺癌骨转移患者采用GP或EP方案化疗,治疗前uDPD/Cr(12.85±2.52)nmol/ mmol,治疗后uDPD/Cr下降为(8.43±2.63)nmol/ mmol,差异有统计学意义(P＜0.05).结论 uDPD检测在肺癌骨转移诊断与治疗评估中具有重要意义.%Objective To evaluate the application of urinary deoxypyridinoline (uDPD) in diagnosis and treatment of osseous metastasis of lung cancer.Methods Urinary DPD was detected in 202 patients with lung carcinoma and the uDPD/Cr was compared between patients with or without osseous metastasis.Sensitivity and specificity of uDPD/Cr for diagnosis of osseous metastasis of lung cancer was calculated.Fifty patients with osseous metastasis were treated with pamidronate (n=25) or chemotherapy (n=30) for 2 weeks, and the uDPD/Cr value of 2 groups were tested and compared.Results The sensitivity and specificity of uDPD/Cr for diagnosis of osseous metastasis of lung cancer were 81.4％ and 70.0％ respectively.In pamidronate group the uDPD/Cr was (13.37± 2.65) nmol/ mmol and (7.34± 2.15)nmol/ mmol before and after treatment (P ＜0.01).in chemotherapy group uDPD/Cr was (12.85± 2.52)nmol/ mmol and (8.43± 2.63)nmol/ mmol before and after treatment (P＜0.05).Conclusion Detection of uDPD is ofvalue in diagnosis and assessment oftherapeutic effect in lung cancer with osseous metastasis.