目的评价治疗前血清Th1细胞因子（IL-2、TNF-α和IFN-γ）浓度在鼻咽癌放化疗中对患者远期生存的影响。方法使用流式细胞小球微阵列术检测80例鼻咽癌患者治疗前血清Th1细胞因子水平，使用Kaplan- Meier法绘制生存曲线，使用COX回归法分析细胞因子水平与患者总生存（OS）之间的关系。结果非角化性鼻咽癌上IFN-γ水平较角化性癌升高（P=0.012）；Th1细胞因子水平与患者放化疗治疗效果差异无统计学意义（P＞0.05），治疗前TNF-α高浓度组患者预后明显不如低浓度组（P=0.015），治疗前IL-2高浓度组患者预后明显好于低浓度组（P=0.048）。结论鼻咽癌患者治疗前TNF-α及IL-2水平是预后的独立预测因素。%Objective To investigate the correlation of serum Th1 cytokine levels with long- term survival of patients with nasopharyngeal carcinoma(NPC). Methods Pretreatment serum Th1 cytokines IFN- γ, TNF- αand IL- 2 were detected by cy-tometric bead array(CBA) method in 80 NPC patients undergoing chemoradiotherapy. The survival of patients was measured by Kaplan- Meier curve. The association between cytokine levels and the overal survival (OS) of patients were evaluated with Cox regression analysis. Results Serum IFN- γ levels in patients with non- keratinizing carcinoma were higher than that with kera-tinizing carcinoma (P=0.012). The pretreatment serum IFN- γ, TNF- α and IL- 2 levels were not significantly correlated with treatment response (P>0.05) adjusted for age, gender, TNM stage and tumor cel histology of patients. Higher pretreatment serum TNF- α levels were significantly associated with poorer survival (P =0.015). Patients with a higher pretreatment serum IL- 2 levels had a significantly longer survival than patients with lower levels(P=0.048). Conclusion High serum TNF- level and low IL- 2 level may predict unfavorable prognosis in patients with NPC.
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