IL-18基因启动子-607C/A位点多态性与原发性肝癌发病风险相关性的Meta分析

摘要

目的 系统评价IL-18基因启动子-607C/A位点多态性与原发性肝癌(HCC)发病风险的相关性.方法 计算机检索PubMed、Web of Science、The Cochrane Library(2016年7期)、CNKI、WanFang Data、VlP和CBM数据库,搜集有关IL-18基因启动子-607C/A位点多态性与HCC发病风险相关性的病例对照研究,检索时限均为建库至2016年8月.2位研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用Stata 12.0软件进行Meta分析.结果 最终纳入7个病例对照研究,包括HCC患者1 021例和对照者1 696例.Meta分析结果显示IL-18基因启动子-607C/A位点多态性与HCC发病风险均无相关性,其中A vsC(OR=1.05,95％CI:0.87～1.27,P=0.63);AA+CA vs CC(0R=1.06,95％CI:0.88～1.27,P=0.56);AA vs CA+CC(OR=1.05,95％CI:0.73～1.51,P=0.79);AA vs CC (OR=1.19,95％CI:0.77～1.84,P=0.44);CA vs CC(OR=1.05,95％ CI:0.87～1.28,P=0.60);AA+CC vs CA(OR=0.95,95％CI:0.81～1.11,P=0.50).按照人种、基础疾病和对照来源进行亚组分析,IL-18基因启动子-607C/A位点多态性与HCC发病风险均无相关性(均P＞0.05).结论 现有证据尚不支持IL-18基因启动子-607C/A位点多态性与HCC发病风险相关;受纳入研究的数量和质量限制,这一结论仍需更多大样本、高质量研究进一步验证.%Objective To assess the association between IL-18 gene promoter-607C/A polymorphism and the risk of hepatocellular carcinoma (HCC).Methods Electronic databases PubMed,Web of Science,The Cochrane Library (Issue 7,2016),CNKI,WanFang Data,VIP and CBM from inception to August 2016 were searched for case-control studies on the association between IL-18 gene promoter-607C/A polymorphism and the risk of HCC.Two reviewers independently screened literatures,extracted data and assessed the risk of biases of included studies.Meta-analysis was performed using Stata 12.0 software.Results Seven case-control studies involving 1 021 HCC cases and 1 696 controls were included.The results of meta-analysis showed that there was no significant association between IL-18 single-nucleotide polymorphism and the risk of HCC(A vs C,OR=1.05,95％CI:0.87-1.27,P=0.63,AA+CA vs CC,OR=1.06,95％CI:0.88-1.27,P=0.56,AA vs CA+CC,OR=1.05,95％C/:0.73-1.51,P=0.79,AA vs CC,OR=1.19,95％CI:0.77-1.84,P=0.44,CA vs CC,OR=1.05,95％CI:0.87-1.28,P=0.60,AA+CC vs CA:OR=0.95,95％ CI:0.81-1.11,P=0.50).According to subgroup-analysis by ethnicity,underlying disease and control source,no significant association was found between IL-18 gene promoter-607C/A polymorphism and the risk of HCC as well.Conclusion On the basis of current evidence,the-607C/A polymorphism in IL-18 gene promoter is not associated with the risk of HCC.Due to the limited quantity and quality of included data,more large-scale,high-quality studies are needed to verify the above conclusion.