浙江中北部农村居民代谢综合征与慢性肾脏病关系的调查研究

摘要

Objective To survey the prevalence of metabolic syndrome (MS) and chronic kidney disease(CKD) among rural residents of north-central region of Zhejiang province and to investigate the association between two diseases. Methods A cross-sectional survey on the prevalence of MS and CKD was conducted with questionnaire, physical examination and laboratory examination. Total 1 627 residents aged ≥18 years, who had lived in rural area of north-central Zhejiang(Pan'an, Haining and Tongxiang) for ≥5 years, were selected as participants. The age-standardized prevalence of MS and CKD was calculated according the 6th population census of Zhejiang province, and the association between the prevalence of CKD and MS was analyzed. Results In 1 627 participants, there were 218 cases of MS with a prevalence rate of 13.40％ (95％ CI: 12.76～16.20％) and 202 cases of CKD with a prevalence rate of 12.42％ (95％ CI: 8.03～10.85％). Compared to non-MS subjects, the BMI, waist circumference, SBP, DBP, UA,FBG, TG, TC in MS residents were higher (All P＜0.05), and HDL-C was lower (P＜0.05), but there were no significant difference in age, serum creatinine, and LDL-C between the two groups (P ＞ 0.05). The prevalence of CKD in MS patients was higher than that in non-MS residents (22.02％ vs 10.93％, P＜0.05). Conclusion The prevalence of CKD with MS among rural residents in north-central Zhejiang is relatively high, and the prevalence rate of CKD in MS patients is higher than that in non-MS inhabitants. So screening of CKD and early intervention of MS are necessary.%目的探讨浙江中北部农村居民代谢综合征(MS)与慢性肾脏病(CKD)的流行病学特征及两者的关系.方法以浙江中北部(磐安县高二乡、海宁市永福村、海宁市许桥村、桐乡市路家园村)4个不同村落、118个村民小组内居住5年以上的18岁以上原住居民为研究对象,通过问卷调查、体格检查及实验室检查进行横断面调查.根据浙江省第6次人口普查数据中乡村地区人口性别、年龄分布计算MS与CKD标化患病率,比较MS患者与未患MS居民基线特征、CKD患病情况.结果在资料完整的1 627例居民中共筛查出MS患者218例,患病率为13.40％(95％CI:12.76～16.20);CKD患者202例,患病率为12.42 ％(95％CI:8.03～10.85).MS患者BMI、腰围、收缩压、舒张压、尿酸、空腹血糖、TG、TC均高于未患MS居民(均P＜0.05),HDL-C低于未患MS居民(P＜0.05),而年龄、血肌酐、LDL-C与未患MS居民比较均无统计学差异(均P＞0.05).MS患者CKD患病率高于未患MS居民(22.02％ vs 10.93％, P＜0.05).结论浙江中北部农村居民MS和CKD流行现状并不乐观,MS患者CKD患病率高于未患MS居民,开展CKD早期筛查及相关知识的普及,尽早对MS进行干预非常必要.