铁皮石斛与玉竹抗疲劳作用的比较研究

摘要

Objective To compare the anti-fatigue effects of Dendrobium candidum with that of Polygonatum. Methods Twenty-five ICR mice were randomly divided into negative control group, single herb Dendrobium can-didum group, single herb Polygonatum group, Dendrobium candidum compound group, and Polygonatum compound group, with 5 mice in each group. All group were given the corresponding drugs for consecutive 7 days, then un-derwent the swimming test. After that, all mice rested for 2 days, then were intragastrically given the corresponding drug for 30 min and underwent hypoxia experiment. The differences between 2 groups were analyzed. Results The increase in weight was the biggest and swimming time and hypoxia-tolerant time were the longest in Dendrobium candidum compound group(8.60±0.69g, 9.86±0.35min, 28.66±1.28min), followed by those in Polygonatum compound group(7.46±0.55g, 9.02±0.45min, 26.78±1.7min), then those in single herb Dendrobium candidum group(6.40±1.14g, 8.87±1.00min, 24.52±2.32min), single herb Polygonatum group (5.60±1.20g, 8.56±0.69min, 2.38±2.21min), with the least in Negative control group (4.84±0.98g, 7.44±0.91min, 19.92±2.12min). There were significant differences be-tween Dendrobium candidum compound group and single herb group and negative control group and between Den-drobium candidum compound group and Polygonatum compound group (P<0.05). Conclusion Both of Polygonatum and Dendrobium candidum have obvious anti-fatigue effect. The effect of single herb Polygonatum is slightly minor than that of single herb Dendrobium candidum. The Anti-fatigue effect of Dendrobium candidum compound evident-ly surpasses that of Polygonatum Compound.%目的：观察铁皮石斛与玉竹及其配方的抗疲劳作用。方法将ICR小鼠25只随机分为阴性对照组、单味铁皮石斛组、单味玉竹组、铁皮石斛复方组、玉竹复方组，每组5只，连续给药1周（7天）后进行游泳实验，小鼠休息2天后，灌胃相应药物30min后进行耐缺氧实验，记录数据，对比并分析各组的差异。结果小鼠体质量增长、游泳时间和耐缺氧时间，呈现复方铁皮石斛组[（8.60±0.69）g、（9.86±0.35）min、（28.66±1.28）min]>复方玉竹组[（7.46±0.55）g、（9.02±0.45）min、（26.78±1.27）min]>单味铁皮石斛组[（6.40±1.14）g、（8.78±1.00）min、（24.52±2.32）min]>单味玉竹组[（5.60±1.20）g、（8.56±0.69）min、（23.38±2.21）min]>对照组[（4.84±0.98）g、（7.44±0.91）min、（19.92±2.12）min]，且复方组明显高于其它三组（P<0.05）。结论铁皮石斛和玉竹均有显著的抗疲劳作用，单味玉竹的抗疲劳作用略亚于单味铁皮石斛，铁皮石斛复方的抗疲劳效果明显优于玉竹复方。