目的探讨脑梗死患者颈动脉内膜中层厚度（CIMT）与IL-6、IL-10及相关危险因素之间的关系。方法采用多普勒超声诊断仪测量110例脑梗死患者CIMT，根据CIMT值分为CIMT正常组（CIMT<1.0mm）54例，和CIMT增厚组（CIMT≥1.0mm）56例，比较两组患者年龄、性别及血清中总胆固醇（TCH）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、尿酸（UA）、同型半胱氨酸（HCY）、及IL-10，IL-6等指标。结果 CIMT增厚组动脉血栓形成性脑梗死所占比例明显高于CIMT正常组（P=0.003）；CIMT增厚组患者年龄、男性比例、LDL-C、HCY、IL-6、IL-6/IL-10水平明显高于CIMT正常组（P<0.05）；而两组TCH、TG、HDL-C、UA、IL-10水平差异无统计学意义。结论 CIMT增厚与动脉血栓形成性脑梗死密切相关，脑梗死患者CIMT增厚受多种因素影响，尤其与年龄、性别、LDL-C、HCY水平密切相关，IL-6、IL-6/IL-10升高，可能参与了脑梗死患者动脉粥样硬化的发生发展，是CIMT增厚的重要因素之一。% Objective To investigate the relationship between carotid intima-media thickness(CIMT)and serum IL-6、IL-10、the related risk factors in patients with ischemic stroke.Methods CIMT of 110 cases of patients with ischemic stroke were measured by Color Doppler ultrasound.Then all patients were divided into two groups by the value of CIMT:54 patients with normal CIMT(CIMT<1.0mm),56 patients with higher CIMT(CIMT≥1.0mm). Levers of TCH、TG、LDL-C、HDL-C、HCY、 UA、IL-6andIL-10 in serum were measured in all patients. Results CIMT bodiness obviously in large-artery atherosclerosis(LAA),and the difference had statistical significance(P=0.003). Compared with normal CIMT、AGE、LDL-C、HCY、IL-6and IL-6/IL-10 increased in higher CIMT,and the differences had statistical significance (P<0.05). Conclusion CIMT bodiness plays a very important role in large-artery atherosclerosis(LAA). CIMT bodiness is influenced by various kinds of factors,and which is highly associated with sex、age、TCH、LDL-C and HCY.Serum concentrations of IL-6 increase significantly in patients with higher CIMT. IL-6、IL-10 may take part in the development of artherosclerosis in patients with ischemic stroke,and higher level of IL-6、IL-6/IL-10 is an important risk factor for the increase CIMT.
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