联合检测血胃蛋白酶原和糖类抗原724在胃癌诊断中的价值

摘要

Objective To study the diagnostic value of serum pepsinogen(PG)and carbohydrate antigen 724(CA72-4)in gastric cancer. Methods 107 patients with gastric cancer,who were diagnosed by surgery and pathology during Jan.2012 to May 2015,were studied as gastric cancer group.100 people who came for a healthy check-up during the same time were chosen as control group. Radiation immunity analysis was used to study the expression of PG and CA72-4 in these two groups. Comparison analysis was used for the data. Results The expression of PGI and PG I/PG Ⅱin gastric cancer group was obviously lower than the control group(P<0.01),while the expression of CA72-4 was obviously higher than the control group(P<0.01). The positive rate of single test for PG or CA72-4 was much lower than joint test of PG and CA72-4. Conclusion Joint test of PG and CA72-4 has a diagnostic significance for gastric cance.%目的：探讨血清胃蛋白酶原（PG）、糖类抗原724（CA724）对胃癌诊断的价值。方法选择2012年1月至20l5年5月经临床手术及病理确诊的胃癌患者107例作为胃癌组。选择同期健康体检者100例作为对照组。采用放射免疫分析法检测两组受试者的血清PG、CA724，并进行两组对照分析。结果胃癌组血清PGI、PG I/PG Ⅱ水平显著低于对照组（P<0.01）、CA724水平显著高于对照组（P<0.01）。单一检测血清PG或CA724的阳性率低于联合检测的阳性率（P<0.05）。结论联合检测血清PG和CA724对胃癌的诊断有较高的价值。