Objective To explore the scanning of tuberculosis biomarkers. Methods The enzyme-linked immunosorbent assays aimed on proteins related with the inflammatory state were performed. Result Alpha-1-antichymotrypsin(AACT),clusterin(CLU),and Ig alpha-1 chain C region(IGHA1) showed significantly reduced levels in cured pulmonary tuberculosis(TB) patients than untreated ones. Furthermore,the decision model established by these three proteins reached a sensitivity of 79.59％,and a specificity of 77.36％. Conclusion It is suggested that AACT,CLU, IGHA1 may be served as potential biomarkers for curing TB.%目的 探讨肺结核病蛋白质标志物的筛选方法.方法 利用酶联免疫吸附法筛选肺结核病的治愈标志物.结果 α-1抗胰糜蛋白酶(AACT)、丛生蛋白(CLU)、免疫球蛋白α-1链C区(IGHA1)3个蛋白质在治愈肺结核病患者中均较未用药组显著降低,并且由这3个蛋白质构建的判定模型的敏感度达79.59％,特异度达77.36％.结论 AACT、CLU、IGHA1有可能成为治愈肺结核病的血清标志物.
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