Objective To study the relationship between the cognitive disorder and the neurologic impairment and activity of daily living in patients with acute cerebral infarction,and the impacts on prognoses of early intervention using the Reinhardt and Sea Cucumber Capsule(RSC). Methods 153 patients with acute cerebral infarction were divided into 2 groups based on cognitive ratings one week after hospitalization,with one being the normal group consistinged 56 patients and the other one being the special group of 97 patients who were found havingd a cognitive disorder. The special group was further randomly divided into observation group(50 cases)and control group(47 cases). All patients were treated by conventional therapy for cerebral infarction. Patients in the observation group took the RSC three times a day with three pills at each time during three-month course of treatment. All patients received the MMSE,NIHSS and Barthel index ratings prior to and post- treatment. Electrocardiogram,blood routine indicators,liver and renal functions,blood sugar and electrolyte were also examined before and after treatment. Results Except for the MMSE scores in the normal group,differences of scores in each rating from the remaining patients before and after treatment were of statistical significance (P<0.01). The NIHSS scores in the normal group were lower than other two groups after treatment(P<0.05 or P<0.01),while the Barthel index was higher(P<0.05 or P<0.01). The MMSE scores in the observation group were higher than that of the control group(P<0.01)while the NIHSS scores were lower(P<0.05)and the Barthel index was higher(P<0.05). 2 patients in the observation group were found hadving rashes which were cured by anti-allergic therapy and they did not stop taking the RSC. No severe impairments of liver,kidney and blood coagulation functions and were found in all patients. Conclusion The cognitive disorder has significant impacts on the rehabilitation of neurological functions in patients with acute cerebral infarction. Early intervention using the RSC has positive effects on prognoses of patients.%目的 探讨脑梗死急性期患者认知功能障碍与神经功能缺损及日常生活活动能力的关系及复方海蛇胶囊早期干预对患者预后的影响.方法 153例急性期脑梗死患者住院1周后按认知功能评定分为两组,即认知功能正常组56例,认知功能障碍组97例,认知功能障碍组随机分为观察组(50例)和对照组(47例).所有患者均按常规脑梗死治疗方法进行治疗,观察组加用复方海蛇胶囊口服,3粒/次,3次/d;疗程3个月,所有患者治疗前后以MMSE,NIHSS,Barthel指数进行评分,治疗前后检查心电图、血常规、肝肾功能、血糖、电解质等.结果 除正常组MMSE评分外,治疗后各项评分与治疗前比较,差异均有统计学意义(P<0.01).治疗后认知功能正常组患者NIHSS评分低于其它两组(P<0.05或P<0.01),Barthel指数高于其它两组(P<0.05或P<0.01).观察组患者MMSE高于对照组(P<0.01),NIHSS评分低于对照组(P<0.05),Barthel指数高于对照组(P<0.05).观察组中有2例患者出现皮疹,经抗过敏治疗后皮疹消失,未停用治疗药物.所有患者中均未发现有肝肾功能及凝血功能的严重损害.结论 认知功能障碍对急性脑梗死患者神经功能康复有重要影响,而早期使用复方海蛇胶囊干预对患者预后有积极的效果.
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