目的 探讨宫颈癌在超声造影检查中的影像特征及其与ki67抗原的相关性.方法 选取2015年1月至2016年3月确诊为宫颈癌而行手术治疗的患者40例(所有患者均得到术后病理学检查证实),均在手术前接受超声造影检查并获得峰值强度(PI)、显影时间(AT)及达峰时间(TTP)等超声造影参数,并与术后组织标本进行免疫组化检查所获的细胞核增殖抗原(ki67抗原)表达情况作比较分析.结果 宫颈癌组织的AT和TTP较正常宫颈组织呈现明显减少,差异有统计学意义(P＜0.05);宫颈癌组织PI较正常宫颈组织呈现明显增大,差异有统计学意义(P＜0.05);ki67阳性宫颈癌组织中增强不匀、灌注缺损的出现率较ki67阴性宫颈癌组织增大,差异有统计学意义(P＜0.05);ki67阳性宫颈癌组织的AT和TTP较ki67阴性宫颈癌组织明显减少,差异有统计学意义(P＜0.05);ki67阳性宫颈癌组织的PI较ki67阴性宫颈癌组织明显增大,差异有统计学意义(P＜0.05).结论 宫颈癌在超声造影检查中有特征性的形态学改变,并与ki67抗原的表达情况存在一定关系,可为宫颈癌的临床诊疗及预后提供参考依据.%Objective To explore the features of cervical cancer in contrast-enhanced ultrasound (CEU) and its correlation with nuclear proliferation antigen (ki67 antigen).Methods A total of 40 cases (confirmed by postoperative pathology) who had the surgical treatment in patients with cervical cancer were selected during 2015-1 to 2016-3 in our hospital, preoperatively accepted CEU and got peak intensity (PI), arrival time (AT) and time to peak (TTP), compared with ki67 antigen expression of postoperative tissue samples got by immunohistochemical examination.Results AT and TTP in cervical cancer tissue reduced obviously than those in normal cervical tissue (P＜0.05);PI in cervical cancer tissue increased obviously than that in normal cervical tissues (P＜0.05).The emergence rate of uneven enhancement, perfusion defect in Ki67 positive cervical cancer tissue increased obviously than those in the ki67 negative cervical cancer tissue (P＜0.05);AT and TTP in Ki67 positive cervical cancer ki67 decreased significantly than those in negative cervical cancer tissue (P＜0.05);PI in Ki67 positive cervical cancer tissue increased obviously than that in ki67 negative cervical cancer tissue (P＜0.05).Conclusion Cervical cancer has the characteristic morphological changes in CEU, and there is a certain relationship with ki67 antigen expression, can provide reference for the clinical diagnosis, treatment and prognosis of cervical cancer.
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