高龄慢性心衰急性发作患者入院脑钠肽与近期预后相关性

摘要

Objective To investigate the relationship between the level of plasma Brain Natriuretic Peptide(BNP) and the short-term efficacy of elderly patients with acute heart failure. Methods Randomized selection of 31 patients more than 75 years old with chronic heart failure due to acute exacerbation. Plasma BNP level was measured at admission and left ventricular end diastolic diameter, left ventricular end systolic diameter, left ventricular ejection fraction and cardiac output were measured by color Doppler ultrasonography. The level of BNP, color Doppler echocardiography and the correlation between BNP, left ventricular ejection fraction and final outcome were measured at different level of cardiac function at admission. Result The left ventricular ejection fraction and the cardiac output were gradually decreased and the difference was significant (P<0.05). The left ventricular end-diastolic diameter and the left ventricular end-systolic diameter increased gradually with the increase of the degree of heart failure. Patients with BNP were significantly higher than other patients and the left ventricular ejection fraction was lower than the other two groups with significant difference. Conclusion The level of BNP in elderly patients with acute congestive heart failure is positively correlated with the level of cardiac function. It is of great significance to clinical prognosis.%目的 通过对高龄心功能不全急性发作患者入院时血浆脑钠肽(BNP)水平与患者近期疗效进行分析,发现两者之间相关性.方法 随机选择年龄≥75岁因慢性心功能不全急性发作住院治疗31例患者入组.入院时检测血浆BNP水平、彩色多普勒超声测量左室舒张末期内径(LVD)、左室收缩末期内径(LVS)、左室射血分数(LVEF)、心输出量(CO).分析入院时不同级别心功能患者的BNP水平、彩色多普勒超声心功能状况;入院时BNP、LVEF与最终转归的相关性.结果 入院时,随着心衰程度的加重,BNP水平逐渐增高;LVD、LVS逐渐增大,LVEF、CO逐渐降低,差异均具有统计学意义(P<0.05).死亡组患者BNP显著高于其他患者,LVEF低于其他两组,差异有统计学意义(P<0.05).结论 高龄老年慢性充血性心力衰竭急性发作患者入院BNP水平与其心功能级别呈正相关,并且对其临床近期预后具有指导意义,值得高度关注.