cqvip:Objective: To compare the incidence of admissions to hos- pital for stroke among older adults with dementia receiving atypical or typica l antipsychotics. Design:Population based retrospective cohort study. Setting:On tario, Canada. Patients: 32 710 older adults (≥65years) with dementia (17 845 d ispensed an atypical antipsychotic and 14 865 dispensed a typical antipsychotic) .Main outcome measures: Admission to hospital with the most responsible diagnosi s (single most important condition responsible for the patient’s admission) of i schaemic stroke. Observation of patients until they were either admitted to hosp ital with ischaemic stroke, stopped taking antipsychotics, died, or the study en ded. Results: After adjustment for potential confounders, participants receiving atypical antipsychotics showed no significant increase in risk of ischaemic str oke compared with those receiving typical antipsychotics (adjusted hazard ratio 1.01, 95%confidence interval 0.81 to 1.26). This finding was consistent in a se ries of subgroup analyses, including ones of individual atypical antipsychotic d rugs (risperidone, olanzapine,and quetiapine) and selected subpopulations of the main cohorts. Conclusion: Older adults with dementia who take atypical antipsyc hotics have a similar risk of ischaemic stroke to those taking typical antipsych otics.
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