Background: Ultralow- fat diets are known to reduce high- density lipoprotein cholesterol(HDL- C) levels. In the setting of a multicomponent lifestyle intervention program, relationships between exercise variables and HDL- C levels were examined to determine whether exercise moderates this dietary effect on serum lipids and apolipoproteins. Methods: We performed a 3- month, prospective, nonrandomized lifestyle intervention study(≤ 10% dietary fat; aerobic exercise [180 min/wk], group support, and yoga [60 min/day]) in 120 subjects with or at risk for coronary artery disease. Results: After 3 months, dietary fat intake was reduced to 8.7% ± 2.6% of total intake and the median weekly exercise time was 194 minutes. High- density lipoprotein cholesterol levels decreased by 8.3± 11.3 mg/dL(P194 min/wk, HDL- C was reduced compared with baseline(- 7.4± 7.9 mg/dL, P< .001). Conclusions: An ultralow- fat diet as a component of a comprehensive lifestyle intervention induces reductions in HDL- C and the emergence of a dyslipidemic lipid profile. Aerobic exercise only partially mitigates this effect.
展开▼
