动态观察免疫性肝病相关自身抗体变化及临床价值

摘要

Objective To explore the changes and clinical application value of immune related autoantibodies in patients with autoimmune liver diseases.Methods 121 cases of hospitalized patients with autoimmune liver disease (AILD) were selected as the observation objects, and the patients were divided into groups according to the clinical diagnosis, Divided into AIH group of 64 cases and PBC group of 57 cases, and selected 80 cases of healthy physical examination results as a healthy control group, In the process of treatment according to the condition of patients treated with hormone therapy, ursodeoxycholic acid, azathioprine treatment, and antibody detection and detection of liver function.ResultsThe AIH and PBC groups were signiifcantly different in AMA-M2 antibody, Sp100 antibody, LKM-1 antibody, LC-1 antibody and SLA antibody, There was no signiifcant difference in positive detection rate and titer between different treatment time (P>0.05), and there was no signiifcant difference between patients with different drugs (P>0.05). Conclusion It is very important for the diagnosis and differential diagnosis of AILD in the diagnosis and differential diagnosis, but it does not change with the remission of the disease, and it can not be used as an indicator of clinical curative effect observation.%目的：探究动态观察免疫性肝病相关自身抗体的变化及临床应用价值。方法选取本院诊断为自身免疫性肝病（AILD）的住院患者121例为观察对象，并根据临床诊断进行分组，分为AIH组64例和PBC组57例，并选取同期体检结果健康的80例作为健康对照组，在治疗的过程中根据患者的情况给予激素治疗、熊脱氧胆酸、硫唑嘌呤等治疗，并进行抗体检测及肝功能检测。结果 AIH及PBC组患者在AMA-M2抗体、Sp100抗体、LKM-1抗体、LC-1抗体、SLA抗体具有显著性差异，不同治疗时间上阳性检出率及滴度间均不存在显著性差异（P>0.05），不同药物间治疗的患者差异亦不显著（P>0.05）。结论自身抗体检测对于AILD的诊断、鉴别诊断具有非常重要的作用，但不随病情缓解而改变，不能作为临床疗效观察的指标。