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From Osteoblast to Osteoclast:New Insights of Yin-Yang Theory in Bone Remodeling

机译:从成骨细胞到破骨细胞:阴阳学说在骨重建中的新见解

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摘要

Yin-Yang theory plays critical role in traditional Chinese medicine (TCM) science. However, there are many competing interpretations of Yin-Yang theory in the context with the development in biology, and no consensus has been established. Here we first propose that osteoblast should be regarded as Yin, while osteoclast should be considered as Yang in bone remodeling compartment (BRC). Our conceptions are consistent with the following key findings:1)osteoblast and osteoclast both derive from the embryonic ectoderm;2)osteoblast and osteoclast work collaboratively in BRC to maintain bone homeostasis;3)the activities of osteoblast and osteoclast are coupled to remain dynamic balance;4)osteoblast and osteoclast exert their function in ceaseless successions. Moreover, we argue that Yin-Yang relationships exist between osteoblast and osteoclast: osteoblast secretes the receptor activator for nuclear factor-κB ligand (RANKL) and the monocyte/macrophage colony-stimulating factor (M-CSF) and osteoprotegerin (OPG) to positively or negatively regulate osteoclast differentiation and function. Meanwile, osteoclast and bone resorption in turn release cytokines, such as transforming growth factor-β(TGF-β), insulin-like growth factor-1 (IGF-1) from bone matrix, to regulate osteoblast differentiation and function. Next, the unlimited division of Yin-Yang can be applied to divide sublevel of Yin-Yang inside osteoblast or osteoclast. Finally, Yin-Yang relationship of osteoblast and osteoclast is relative. Therefore, we come into the conclusion that the relationships between osteoblast and osteoclast as established in contemporary biology reflect the classic Yin-Yang in bone remodeling. The new Yin-Yang concepts of osteoblast and osteoclast may strengthen basic theory and clinical practice in TCM.
机译:阴阳理论在中医药学中起着至关重要的作用。但是,随着生物学的发展,对阴阳理论有许多相互竞争的解释,尚未达成共识。在这里,我们首先建议在骨重塑室(BRC)中将成骨细胞视为阴,而将破骨细胞视为阳。我们的构想与以下主要发现相符:1)成骨细胞和破骨细胞均来自胚胎外胚层; 2)成骨细胞和破骨细胞在BRC中协同工作以维持骨稳态; 3)成骨细胞和破骨细胞的活动相互耦合以保持动态平衡; 4)成骨细胞和破骨细胞不断发挥作用。此外,我们认为成骨细胞和破骨细胞之间存在阴阳关系:成骨细胞分泌核因子-κB配体(RANKL)和单核细胞/巨噬细胞集落刺激因子(M-CSF)和骨保护素(OPG)的受体激活剂或负面调节破骨细胞的分化和功能。同时,破骨细胞和骨吸收依次从骨基质释放细胞因子,例如转化生长因子-β(TGF-β),胰岛素样生长因子-1(IGF-1),以调节成骨细胞的分化和功能。接下来,可以使用无限次划分阴阳来划分成骨细胞或破骨细胞内部阴阳的子级别。最后,成骨细胞与破骨细胞的阴阳关系是相对的。因此,我们得出的结论是,在当代生物学中建立的成骨细胞和破骨细胞之间的关系反映了骨重建中的经典阴阳。阴阳新的成骨细胞和破骨细胞概念可能会加强中医的基础理论和临床实践。

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  • 来源
    《世界中医药杂志(英文版)》 |2015年第2期|50-55|共6页
  • 作者单位

    Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;

    Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;

    Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;

    Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;

    Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;

    Department of Pathology, University of Alabama at Birmingham, Alabama, United States of America;

    Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;

    Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;

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  • 入库时间 2022-08-19 03:48:21
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