Toll-like receptor 4 polymorphisms to determine acute pancreatitis susceptibility and severity: A meta-analysis

摘要

AIM:To investigate the correlation of toll-like receptor 4(TLR4)gene Asp299Gly and Thr399Ile polymorphisms and acute pancreatitis(AP)risk and severity.METHODS:To get a more precise estimation of the relationship,a comprehensive search was performed to examine all the eligible studies of TLR4 Asp299Gly and Thr399Ile polymorphisms and AP risk.The odds ratios with 95%confidence intervals were used to assess the strength of the association.Publication bias was analyzed by Begg’s funnel plots.RESULTS:In total,six studies with 1255 cases and998 controls were included in this meta-analysis.Totally,no significant associations were found betweenTLR4 Asp299Gly or Thr399Ile polymorphisms and AP risk using five models with high homogeneity(P>0.05).Furthermore,stratification analysis by ethnicity or assay also found no significant association in these two polymorphisms(P>0.05),and TLR4 Asp299Gly was not associated with AP severity(P>0.05).In addition,no publication bias was found in these studies(P>0.05).CONCLUSION:Our current meta-analysis suggests that TLR4 Asp299Gly and Thr399Ile polymorphisms may not be risk factors to AP susceptibility.